#4452 ICODEXTRIN EFFICIENCY IN FLUID AND SODIUM REMOVAL REMAINS STABLE DURING LONG PERITONEAL DWELLS

Abstract Background and Aims Inadequate fluid sodium removal has been shown to increase risk of overhydration hypertension. In peritoneal dialysis, icodextrin-based solution provides sustained ultrafiltration, therefore can be used for the long exchanges, especially in patients with fast solute transport rates whom effective ultrafiltration period is shortened. We investigated which extent efficiency icodextrin changing during 16-hour dwells. Method Data on intraperitoneal volume, concentrations dialysate 16 hours dwells were analysed 11 clinically stable patients. Labeled serum albumin (RISA) was as a volume marker samples 12 mL collected at 8, 12, dwell. Residual evaluated from dilution after by rinsing cavity 2 L fresh 1.36% glucose dialysis fluid. Ultrafiltration (UF) calculated each patient sampling time difference between drained initially infused corrected sample volume. The total absorption icodextrin-derived carbohydrates (AbsCHO) mass. (UFE) divided amount mass absorbed (AbsCHO). (NaRE) removed (difference mass) corresponding Correction residual collections applied AbsCHO, UFE NaRE calculations. Results After dwell positive all except one patient, being average (mean±SD) 669±369 mL. During dwell, slowly cavity, see Figure 1, left panel. At hours, mean cumulative CHO reached 68.0±20.7 g (44±13% initial while 56% still remained dialysate, Icodextrin UF (p = 0.6, ANOVA repeated measures) 9.9±5.8 mL/g, right Moreover, also 8 1.2±0.7 mmoL/g, Conclusion solution, osmotic agent remaining hours. terms did not subside